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Research Frontiers

Research Frontiers

Industry Frontier | ASN 2026 Complement Research Update

Tissue targeting · mechanism matching · activity assessment—from 68 core complement-related abstracts, what kidney disease research is asking.

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Research Frontiers

Nature Study Maps Immune Responses to Pig Kidney Xenotransplantation

Facing the global organ shortage crisis, gene-edited pig organs are seen as a beacon of hope for saving lives. However, even after gene editing, the strong immune rejection after cross-species…

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Research Frontiers

Prospective case: follow-up of a preoperative Nephrin antibody-positive patient after desensitization treatment

Recently, the magazine "Kidney International" reported a case of a pediatric patient with primary focal segmental glomerulosclerosis (pFSGS) who cleared Nephrin antibodies before kidney…

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Research Frontiers

Frontiers of Xenotransplantation | NEJM Case Report: Gene-edited pig kidney xenotransplantation brings new hope to patients with end-stage renal disease

Recently, the New England Journal of Medicine (NEJM) published a xenotransplantation case report from Massachusetts General Hospital in the United States. Researchers at the hospital successfully…

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Research Frontiers

Industry Frontier | Pig kidney-derived cell-free DNA (xd-cfDNA) enables early warning of xenogeneic kidney transplant rejection

Recently, a study published in the journal Xenotransplantation provides a new and important direction for postoperative monitoring of kidney xenotransplantation. The study was completed by a team of…

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Research Frontiers

2022ATC in-depth interpretation (3): Factors affecting dd-cfDNA detection values

As dd-cfDNA enters the clinical application stage of transplantation, it is necessary to correctly interpret the clinical significance of the detection values. On the one hand, we are required to…

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Research Frontiers

2022ATC in-depth interpretation (2): In-depth correlation analysis between dd-cfDNA detection and Banff pathological indicators

In studies pairing donor-derived cell-free DNA (dd-cfDNA) detection with biopsy pathology, dd-cfDNA has been shown to be diagnostic of rejection. With the deepening of research, clinical trials have…

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Research Frontiers

ATC2022 in-depth interpretation (1): dd-cfDNA clinical usage scenarios and usage experience summary

As the clinical application of dd-cfDNA in kidney transplantation continues to expand, transplant centers around the world continue to deepen their understanding of the synergistic value between…

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Research Frontiers

ATC2022 Review: In-depth interpretation of global progress of dd-cfDNA

From June 4 to 8, the five-day American Transplantation Conference (ATC) was held in Boston, USA. The conference had a forward-looking theme of "The Science of Tomorrow Starts Today" and covered many…

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Research Frontiers

Industry Frontier | Am J Transplant magazine research results reveal the similarities and differences between DSA-positive and DSA-negative mABMR at the clinical manifestations, pathological biopsy and molecular level

On May 16, the American Journal of Organ Transplantation (Am J Transplant) published the results of a study online. The study compared the clinical manifestations, pathological biopsy and…

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Research Frontiers

Industry Frontier | Researchers transform type A blood donor lungs into universal blood type donor lungs through enzymatic treatment

Recently, Canadian researchers say they have found a way to help people who would otherwise languish on the organ transplant list. In their new study, they detail converting lungs from people with…

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Research Frontiers

ATC 2021: dd-cfDNA for Subclinical Screening (Part 3)

The clinical manifestations of subclinical rejection are not obvious, and procedural biopsy is currently the main method to detect subclinical rejection. However, its application is limited due to…

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Research Frontiers

ATC 2021: dd-cfDNA, Risk Stratification and Prognosis (Part 2)

At present, research on donor-derived cell-free DNA (dd-cfDNA) mainly focuses on the diagnosis of rejection, but there are few reports on its use for prognostic factor analysis and risk…

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Research Frontiers

ATC 2021: Perspectives on Donor-derived Cell-free DNA (Part 1)

At this year's American Transplantation Annual Conference (ATC 2021), donor-derived cfDNA (dd-cfDNA), an emerging biomarker in the field of transplantation liquid biopsy, continues to become a…

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Research Frontiers

Transpl Infect Dis: COVID-19 survivors may be safe organ donors

The new coronavirus has been raging around the world for 18 months since it was first reported. While the virus poses a huge threat to human life, it has also profoundly affected the global…

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Research Frontiers

"Nature Reviews Nephrology" published a review: dd-cfDNA can be used to detect kidney transplant damage

Recently, the international authoritative medical journal Nature Reviews Nephrology published a review focusing on the transplant liquid biopsy biomarker—dd-cfDNA. It proposes that clinical…

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Research Frontiers

New York State approves Eurofins Viracor new kidney transplant rejection biomarker test

Eurofins Viracor and Transplant Genomics stated that the New York State Department of Health Clinical Laboratory Evaluation Program (CLEP) has approved the company's Viracor TRAC donor-derived…

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Research Frontiers

Industry Frontier | The impact of urinary tract infection on dd-cfDNA detection values

Urinary tract infection is one of the most common infections after kidney transplantation, with an incidence rate of 20%-80% after transplantation. Studies have suggested that urinary tract infection…

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Research Frontiers

Industry News | NephroSant launches urine sample-based kidney transplant rejection diagnostic product

About 20% of kidney transplant patients require retransplantation every year, and acute rejection is an important factor affecting the long-term survival of the transplanted kidney. Early and…

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Research Frontiers

Science Frontier: Regarding dd-cfDNA, what was discussed at the ATC meeting? (3)

In the last two issues, the editor introduced to you the new progress of donor-derived cell-free DNA (dd-cfDNA) in transplantation liquid biopsy at the ATC conference. In this issue, the editor will…

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Research Frontiers

Science Frontier: Regarding dd-cfDNA, what was discussed at the ATC meeting? (2)

In the last issue, the editor introduced to you the new progress of transplant liquid biopsy (donor-derived cell-free DNA, dd-cfDNA) at the ATC meeting. In this issue, the editor will continue to…

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Research Frontiers

Science Frontier: Regarding dd-cfDNA, what was discussed at the ATC meeting? (1)

Due to the COVID-19 pandemic in 2020, the American Transplant Congress (ATC), originally scheduled for May 30 to June 3 in Philadelphia, was held online for the first time, presenting cutting-edge…

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Research Frontiers

Industry News | CareDx partners with Weill Cornell Medicine to use urine samples to diagnose acute rejection

Recently, CareDx, a molecular diagnostics company focusing on organ transplantation, announced a strategic alliance with Weill Cornell Medicine to use UroMap detection technology to diagnose T…

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Research Frontiers

Transplant Liquid Biopsy | Molecular Stethoscope for Organ Health Monitoring

Organ transplantation is known as one of the three major application fields in the era of liquid biopsy. It is the next emerging direction of liquid biopsy application after non-invasive prenatal…

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Research Frontiers

CareDx launches cell-free DNA-based non-invasive detection product for kidney transplant rejection

CareDx (CNDA), a Nasdaq-listed company based in California, USA, recently released AlloSure, a non-invasive detection product for rejection after kidney transplantation.

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Research Frontiers

To protect the health of transplanted organs, a cutting-edge company raised tens of millions of dollars in Series A financing!

Emerging name: TAI Diagnostics Company location: Wauwatosa, Wisconsin, USA

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Research Frontiers

He Xiaoshun's team at Sun Yat-Sen First Hospital successfully performed the world's first "no ischemia" kidney transplant

Recently, Professor He Xiaoshun’s team at our hospital’s Organ Transplantation Center successfully performed the world’s first “ischemia-free” kidney transplantation. This is the first time that the…

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