ALLODX
Insights & Perspectives
Nature Study Maps Immune Responses to Pig Kidney Xenotransplantation
Facing the global organ shortage crisis, gene-edited pig organs are seen as a ray of hope for saving lives. However, even after gene editing, strong immune rejection after cross-species…
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Prospective case: follow-up of a preoperative Nephrin antibody-positive patient after desensitization treatment
Recently, the magazine "Kidney International" reported a case of a pediatric patient with primary focal segmental glomerulosclerosis (pFSGS) who cleared Nephrin antibodies before kidney…
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Frontiers of Xenotransplantation | NEJM Case Report: Gene-edited pig kidney xenotransplantation brings new hope to patients with end-stage renal disease
Recently, the New England Journal of Medicine (NEJM) published a xenotransplantation case report from Massachusetts General Hospital in the United States. Researchers at the hospital successfully…
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Industry Frontier | Pig kidney-derived cell-free DNA (xd-cfDNA) enables early warning of xenogeneic kidney transplant rejection
Recently, a study published in the journal Xenotransplantation provides a new and important direction for postoperative monitoring of kidney xenotransplantation. The study was completed by a team of…
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2022ATC in-depth interpretation (3): Factors affecting ddcfDNA detection values
As ddcfDNA enters the clinical application stage of transplantation, it is necessary to correctly interpret the clinical significance of the detection values. On the one hand, we are required to…
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2022ATC in-depth interpretation (2): In-depth correlation analysis between ddcfDNA detection and Banff pathological indicators
In studies pairing donor-derived cell-free DNA (ddcfDNA) detection with biopsy pathology, ddcfDNA has been shown to be diagnostic of rejection. With the deepening of research, clinical trials have…
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ATC2022 in-depth interpretation (1): ddcfDNA clinical usage scenarios and usage experience summary
As the clinical application of ddcfDNA in kidney transplantation continues to expand, transplant centers around the world continue to deepen their understanding of the synergistic value between…
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ATC2022 Review: In-depth interpretation of global progress of ddcfDNA
From June 4 to 8, the five-day American Transplantation Conference (ATC) was held in Boston, USA. The conference had a forward-looking theme of "The Science of Tomorrow Starts Today" and covered many…
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Industry Frontier | Am J Transplant magazine research results reveal the similarities and differences between DSA-positive and DSA-negative mABMR at the clinical manifestations, pathological biopsy and molecular level
On May 16, the American Journal of Organ Transplantation (Am J Transplant) published the results of a study online. The study compared the clinical manifestations, pathological biopsy and…
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Industry Frontier | Researchers transform type A blood donor lungs into universal blood type donor lungs through enzymatic treatment
Recently, Canadian researchers say they have found a way to help people who would otherwise languish on the organ transplant list. In their new study, they detail converting lungs from people with…
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ATC 2021: dd-cfDNA for Subclinical Screening (Part 3)
The clinical manifestations of subclinical rejection are not obvious, and procedural biopsy is currently the main method to detect subclinical rejection. However, its application is limited due to…
Read more ↗ATC 2021: dd-cfDNA, Risk Stratification and Prognosis (Part 2)
At present, research on donor-derived cell-free DNA (ddcfDNA) mainly focuses on the diagnosis of rejection, but there are few reports on its use for prognostic factor analysis and risk…
Read more ↗ATC 2021: Perspectives on Donor-derived Cell-free DNA (Part 1)
At this year's American Transplantation Annual Conference (ATC 2021), donor-derived cfDNA (ddcfDNA), an emerging biomarker in the field of transplantation liquid biopsy, continues to become a…
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Transpl Infect Dis: COVID-19 survivors may be safe organ donors
The new coronavirus has been raging around the world for 18 months since it was first reported. While the virus poses a huge threat to human life, it has also profoundly affected the global…
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"Nature Reviews Nephrology" published a review: ddcfDNA can be used to detect kidney transplant damage
Recently, the authoritative international medical journal Nature Reviews Nephrology" published a review, focusing on the analysis of the transplant liquid biopsy marker-ddcfDNA. It is proposed that…
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New York State approves Eurofins Viracor new kidney transplant rejection biomarker test
Eurofins Viracor and Transplant Genomics said the New York State Department of Health's Clinical Laboratory Evaluation Program (CLEP) has approved the company's Viracor TRAC donor-derived cell-free…
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Industry Frontier | The impact of urinary tract infection on ddcfDNA detection values
Urinary tract infection is one of the most common infections after kidney transplantation, with an incidence rate of 20%-80% after transplantation. Studies have suggested that urinary tract infection…
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Industry News | NephroSant launches urine sample-based kidney transplant rejection diagnostic product
About 20% of kidney transplant patients require retransplantation every year, and acute rejection is an important factor affecting the long-term survival of the transplanted kidney. Early and…
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Science Frontier: Regarding ddcfDNA, what was discussed at the ATC meeting? (3)
In the last two issues, the editor introduced to you the new progress of donor-derived cell-free DNA (ddcfDNA) in transplantation liquid biopsy at the ATC conference. In this issue, the editor will…
Read more ↗Science Frontier: Regarding ddcfDNA, what was discussed at the ATC meeting? (2)
In the last issue, the editor introduced to you the new progress of transplant liquid biopsy (donor-derived cell-free DNA, ddcfDNA) at the ATC meeting. In this issue, the editor will continue to…
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Science Frontier: Regarding ddcfDNA, what was discussed at the ATC meeting? (1)
Affected by the COVID-19 epidemic in 2020, the American Annual Transplantation Conference (ATC), originally scheduled to be held in Philadelphia from May 30 to June 3, will be held online for the…
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Industry News | CareDx partners with Weill Cornell Medicine to use urine samples to diagnose acute rejection
Recently, CareDx, a molecular diagnostics company focusing on organ transplantation, announced a strategic alliance with Weill Cornell Medicine to use UroMap detection technology to diagnose T…
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Transplant Liquid Biopsy | Molecular Stethoscope for Organ Health Monitoring
Organ transplantation is known as one of the three major application fields in the era of liquid biopsy. It is the next emerging direction of liquid biopsy application after non-invasive prenatal…
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CareDx launches cell-free DNA-based non-invasive detection product for kidney transplant rejection
CareDx (CNDA), a Nasdaq-listed company based in California, USA, recently released AlloSure, a non-invasive detection product for rejection after kidney transplantation.
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To protect the health of transplanted organs, a cutting-edge company raised tens of millions of dollars in Series A financing!
New name: TAI Diagnostics Company coordinates: Wauwatosa, Wisconsin, USA
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He Xiaoshun's team at Sun Yat-Sen First Hospital successfully performed the world's first "no ischemia" kidney transplant
Recently, Professor He Xiaoshun’s team at our hospital’s Organ Transplantation Center successfully performed the world’s first “ischemia-free” kidney transplantation. This is the first time that the…
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Biomarker Insights: Why Is C3NeF Difficult to Measure Accurately?
C3NeF is one of the functional drivers of abnormal activation of the alternative complement pathway. The key to measuring it accurately lies in whether the functional status of the invertase can be…
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Biomarker Insights: Tracking Donor Cell Dynamics After Cell Infusion
AlloDx has accumulated experience in dd-cfDNA detection methods and application research in the field of transplantation. For allogeneic cell therapy, the Indel detection method with low background…
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Biomarker Insights: Which Monoclonal Antibodies Can Accurately Measure sC5b-9?
AlloDx CompliTCC™ is based on independently developed AD99 and improves selectivity for complete sC5b-9 complexes from the antibody epitope level.
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Why Is sC5b-9 Difficult to Measure Accurately?
The complement system has three entrances but only one common terminal exit. The classical pathway, the lectin pathway, and the alternative pathway can be initiated by different triggers, but…
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Cutting-edge markers | BAFF and APRIL: What is the clinical exploration value of "source indicators" in the pathogenesis of IgA nephropathy?
The clues to the cause of IgA nephropathy (IgAN) may be hidden in two names - BAFF and APRIL. As B cell activating factor (BAFF) and proliferation-inducing ligand (APRIL), they are the "upstream…
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Application of Nephrin Antibodies in Kidney Transplantation
Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation is a major risk factor for renal allograft failure. Studies have shown that the overall recurrence rate of FSGS…
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Growing Interest in Nephrin Antibodies: Choosing a Testing Method
Nephrin antibodies, as a new circulating penetrant factor in podocyte nephropathy, are considered to be of great value in distinguishing MCD (minimal change kidney disease)/FSGS (focal segmental…
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Opportunities and challenges of Nephrin research (Part 1)
Recent studies have shown that anti-Nephrin autoantibodies (Anti-nephrin Ab) play an important role in the occurrence of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS).…
Read more ↗Opportunities and challenges of Nephrin research (Part 2)
Prior to the identification and sequencing of the NPHS1 gene (Nephrin), scientists had begun to explore the characteristics of antibodies that could bind to the glomerular foot process surface and…
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Transplant Q&A: When Should Medication Be Adjusted After BK Virus Is Detected in Urine or Blood?
BK virus (BKV) is a common polyomavirus after kidney transplantation. The infection rate among kidney transplant patients reaches 68%. Some patients (1%~10%) are prone to progress to BK virus-related…
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Can COVID-19 vaccines be used by transplant patients?
With the new coronavirus (COVID-19) vaccine on the market, more and more immigrants are concerned about whether they can use the COVID-19 vaccine? Here, the editor combines the vaccine use FAQs and…
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Zhang Yimou's Public-interest Film on Five Years of Organ Donation and Transplantation in China
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CCTV Public-service Video on Organ Transplantation
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