Clinical Research2022-01

A Nature Portfolio Journal Cites the AlloDx Team's Early dd-cfDNA Research

Recently, the AlloDx team's early paper on the detection technology of kidney transplant donor-derived cell-free DNA (ddcfDNA) was cited once by a Nature sub-journal published in May.

Recently, the AlloDx team's early paper on the detection technology of kidney transplant donor-derived cell-free DNA (ddcfDNA) was cited once by a Nature sub-journal published in May.

AlloDx is currently the only ddcfDNA detection platform from kidney transplant donors recognized by the international medical community in China. Based on the second-generation gene sequencing platform, it uses self-developed ID-Tag seq technology to reduce the background error of second-generation gene sequencing by 1,000 times by enriching cfDNA and reducing background noise interference. It achieves high-precision detection of low-frequency mutations of one thousandth of a percent under ultra-high sequencing depth. It captures and detects ddcfDNA of patients and combines it with the bioinformatics quantitative model HQ-NIT to evaluate the severity of the patient's rejection reaction.

"Nature" is one of the oldest and most prestigious scientific magazines in the world. Its purpose is to "display important discoveries in scientific research to the public and let the public know as early as possible the progress made in every branch of natural science around the world." Unlike most scientific magazines today that focus on a special field, it publishes first-hand research papers from many scientific fields. In many fields of scientific research, many of the most important and cutting-edge research results are published in the form of short messages in Nature.

Some original figures, videos and downloadable materials are provided in Chinese.

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