ALLODX
AlloDx Perspectives
Biomarker Insights: Why Is C3NeF Difficult to Measure Accurately?
C3NeF is one of the functional drivers of abnormal activation of the alternative complement pathway. The key to measuring it accurately lies in whether the functional status of the invertase can be…
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Biomarker Insights: Tracking Donor Cell Dynamics After Cell Infusion
AlloDx has accumulated experience in dd-cfDNA detection methods and application research in the field of transplantation. For allogeneic cell therapy, the Indel detection method with low background…
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Biomarker Insights: Which Monoclonal Antibodies Can Accurately Measure sC5b-9?
AlloDx CompliTCC™ is based on independently developed AD99 and improves selectivity for complete sC5b-9 complexes from the antibody epitope level.
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Why Is sC5b-9 Difficult to Measure Accurately?
The complement system has three entrances but only one common terminal exit. The classical pathway, the lectin pathway, and the alternative pathway can be initiated by different triggers, but…
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Cutting-edge markers | BAFF and APRIL: What is the clinical exploration value of "source indicators" in the pathogenesis of IgA nephropathy?
The clues to the cause of IgA nephropathy (IgAN) may be hidden in two names - BAFF and APRIL. As B cell activating factor (BAFF) and proliferation-inducing ligand (APRIL), they are the "upstream…
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Application of Nephrin Antibodies in Kidney Transplantation
Recurrence of focal segmental glomerulosclerosis (FSGS) after renal transplantation is a major risk factor for renal allograft failure. Studies have shown that the overall recurrence rate of FSGS…
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Growing Interest in Nephrin Antibodies: Choosing a Testing Method
Nephrin antibodies, as a new circulating penetrant factor in podocyte nephropathy, are considered to be of great value in distinguishing MCD (minimal change kidney disease)/FSGS (focal segmental…
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Opportunities and challenges of Nephrin research (Part 1)
Recent studies have shown that anti-Nephrin autoantibodies (Anti-nephrin Ab) play an important role in the occurrence of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS).…
Read more ↗Opportunities and challenges of Nephrin research (Part 2)
Prior to the identification and sequencing of the NPHS1 gene (Nephrin), scientists had begun to explore the characteristics of antibodies that could bind to the glomerular foot process surface and…
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