AlloDx Collaborative Research Publications

Collaborative research results

(Updated to March 2026)

1)MHC class II and PLA2R investigating the epitope presentation deficits driving antibody production in membranous nephropathy.

Ouzaouit A, Wu Z, Garcia HC, Peprah AF, Yan Y, Sun M, Li P, Quan X, Jiang T, Yang Z, Chen H.

https://doi.org/10.1007/s11255-026-05100-9

2)Repeat Donor-Derived Cell-Free DNA Monitoring for Adjunctive Assessment of BK Polyomavirus Nephropathy Clinical Courses.

Zhao G, Zhang H, Chen X, Xu X, Xu S, Yang S, Chen P, Li Y, Wang W, He Y, Li Q, Qiu J, Fu Q, Deng R, Wu C, Li J, Huang G.

https://doi.org/10.1002/jmv.70856

3)Copy number variations in urine cell-free DNA from bladder neoplasm patients

Haider CG, Wang Q, Wang G, Wang Y, Fu Y, Zhang Z, Cao C, Xue F, Liu H, Wang Q, Zhou J, Jiang T, Cao J, Zhou Y.

https://doi.org/10.1016/j.mcp.2025.102044

4)Urinary and plasma donor-derived cell-free DNA for noninvasive monitoring of BK polyomavirus-associated nephropathy in kidney transplant recipients: a prospective cohort study.

Guo, L., Luo, S., Shen, R., Yan, P., Wang, M., Zhang, T., … Wang, R.

https://doi.org/10.1080/0886022X.2025.2521452

5)Optimized multiplex PCR-NGS for comprehensive HLA genotyping in Chinese populations: resolving ambiguities at high resolution.

Haider Cuello Garcia , Sun Binbin , Wang Yinfeng , Zhang Zhoufan , Cao Changling , Zhu Yiying , Abdelhak Ouzaouit , Huang Huiqiang , Liu Haitao , Jiang Tingya , Dong Xueping , Zhou Yang , Wu Yu.

https://doi.org/10.3389/fimmu.2025.1551173

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6)Circulating anti-nephrin antibody as permeability factor for inducing primary focal segmental glomerular sclerosis and minimal change disease

Jiazhi Li, Yue Yan, Abdelhak Ouzaouit, Jinglei Wang, Zhou Yang, Haifeng Shi, Addai Frank Peprah, Tingya Jiang, Yanhua Lai.

https://doi.org/10.1016/j.nexres.2025.100345

7)Continuous Monitoring of Donor-Derived Cell-Free DNA:Guiding Diagnosis and Management of Subclinical Rejection

Dongrui Cheng，Cuello Garcia Haider，Xue Li，Kenan Xie，Xuefeng Ni，Yang Zhou，Sicheng Wu，
Xiaohui Xu，Tingya Jiang，Jinsong Chen.

https://www.ectrx.org/detail/current/2025/23/2/0/158/0

8)Diagnostic value of three urine miRNAs composite score in BK virus nephropathy

Zhang Z, Cao C, Garcia Haider C, Wang Y, Zhu Y, Abdelhak O, Liu H, Yu C, Chang S, Zhang W, Jiang T, Zhou Y.

https://doi.org/10.1016/j.cca.2025.120162

9)Donor-derived cell-free DNA-based liquid biopsies to determine future kidney transplant rejection

Wang W, Haider CG, Wang Y, Zhang Z, Liu Y, Xue F, Liu H, Jiang T, Cao J, Zhou Y.

https://doi.org/10.23876/j.krcp.23.286

10)Analysis of the primary factors influencing donor derived cell-free DNA testing in kidney transplantation

Cao C, Yuan L, Wang Y, Liu H,Cuello Garcia H, Huang H, Tan W,Zhou Y, Shi H and Jiang T.

https://doi.org/10.3389/fimmu.2024.1435578

11)Cell-Free Mitochondrial DNA: An Upcoming Non-Invasive Tool for Diagnosis of BK Polyomavirus-Associated Nephropathy

Guo L, Luo S, Wang X, Zhang N, Cheng Y, Shen J, Chen J, Wang R.

https://doi.org/10.3390/biom14030348

12)Differentiation between lung allograft rejection and infection using donor-derived cell-free DNA and pathogen detection by metagenomic next-generation sequencing

Chunrong Ju, Lulin Wang, Peihang Xu, Xiaohua Wang, Dong Xiang, Yu Xu, Xin Xu, Rongchang Chen,Jianxing He.

DOI: 10.1016/j.heliyon.2023.e22274

13) Application of plasma donor-derived cell free DNA for lung allograft rejection diagnosis in lung transplant recipients

Chunrong Ju, Lulin Wang, Peihang Xu, Xiaohua Wang, Dong Xiang, Yu Xu, Xin Xu, Rongchang Chen,Jianxing He.

https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-02229-y

14) Using Both Plasma and Urine Donor-Derived Cell-Free DNA to Identify Various Renal Allograft Injuries

Xu-Tao Chen, Jiang Qiu, Zi-Xuan Wu, Hui Zhang, Tong Chen, Shi-Cong Yang, Guo-Dong Zhao, Yu He, Xue Shen, Jin-Quan Luo, Yang Huang, Chang-Xi Wang, Li-Zhong Chen, Cheng-Lin Wu, Gang Huang.

Clinical Chemistry, hvac053, https://doi.org/10.1093/clinchem/hvac053

15) Analysis of cell-free fetal DNA in 16,843 pregnant women from a single center in China using targeted sequencing approach

Yang Zhou , Yinfeng Wang , Frank Peprah Addai , Xiaofeng Li , Xiuwen Zhang , Haitao Liu , Gongda Yang , Fengbo Zeng , Tingya Jiang , Junling Liu.

https://doi.org/10.1016/j.placenta.2022.03.126

16) Plasma donor-derived cell-free DNA levels are associated with the inflammatory burden and macrophage extracellular trap activity in renal allografts.

Luying Guo , Jia Shen , Wenhua Lei , Pengpeng Yan , Meifang Wang , Qin Zhou , Huiping Wang , Jianyong Wu , Jianghua Chen.

https://www.frontiersin.org/articles/10.3389/fimmu.2022.796326/abstract

17) Dynamics of Donor-Derived Cell-Free DNA at the Early Phase After Pediatric Kidney Transplantation: A Prospective Cohort Study

Nie W, Su X, Liu L, Li J, Fu Q, Li X, Wu C, Wang J, Deng R, Chen E, Yang S, Li S, Zhang H, Wang C.

Front Med (Lausanne). 2022 Jan 7;8:814517.

18) Donor-derived cell-free DNA: An independent biomarker in kidney transplant patients with antibody-mediated rejection

Cheng D, Liu F, Xie K, Zeng C, Li X, Ni X, Ge J, Shu L, Zhou Y, Shi H, Liu H, Chen J.

Transpl Immunol. 2021 Dec;69:101404.

19) Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus nephropathy

Shen J, Guo L, Lei W, Liu S, Yan P, Liu H, Zhou J, Zhou Q, Liu F, Jiang T, Wang H, Wu J, Chen J, Wang R.

J Zhejiang Univ Sci B. 2021 Nov 15;22(11):917-928. English.

20) A novel urine cell-free DNA preservation solution and its application in kidney transplantation

Zhou Q, Liu F, Guo L, Chen R, Yuan X, Li C, Shu L, Liu H, Zhou Y, Wu Y, Shi H, Zhao H, Jiang T.

Nephrology (Carlton). 2021 Aug;26(8):684-691.

21) The role of donor-derived cell-free DNA in the detection of renal allograft injury

Zhou Y, Cheng D, Jiang T. Nephrol Ther. 2021 Feb;17(1):12-17.

22) Preliminary clinical experience applying donor-derived cell-free DNA to discern rejection in pediatric liver transplant recipients

Zhao D, Zhou T, Luo Y, Wu C, Xu D, Zhong C, Cong W, Liu Q, Zhang J, Xia Q.

Sci Rep. 2021 Jan 13;11(1):1138.

23) Prognostic value of the donor‐derived cell‐free DNA assay in acute renal rejection therapy: A prospective cohort study

Shen J, Guo L, Yan P, Zhou J, Zhou Q, Lei W, Liu H, Liu G, Lv J, Liu F, Huang H, Dong W, Shu L, Wang H, Wu J, Chen J, Wang R.

Clin Transplant. 2020 Oct;34(10):e14053.

24) Urine Donor–Derived Cell-Free DNA Helps Discriminate BKPyAN in Kidney Transplant Recipients With BK Polyomavirus Infection

Chen XT, Chen WF, Li J, Deng RH, Huang Y, Yang SC, Chen PS, Jiang TY, Liu HT, Wang CX, Chen LZ, Qiu J, Huang G.

Front Immunol. 2020 Aug 19;11:1763.

25) Application of chimeric antigen receptor regulatory T cell immunotherapy in organ transplantation

Wu Yu, Li Peilu, Ge Jun, Jiang Tingya, "Organ Transplantation" 2020,11(5):547-552

26) Donor-Derived Cell-Free DNA in Urine Identifies BKVN with Graft Injury in BK Viruria Kidney Transplant Recipients

Huang G, Chen X, Yang S, Chen W, Chen P, Hou X, Jiang T, Liu H, Li X, Wang C.[abstract].

Am J Transplant. 2019; 19 (suppl 3).

27) Donor-derived Cell-free Dna In Donor Specific Antibody Positive Kidney Transplant Recipients

Cheng D, Li X, Jiang T, Liu H, Zhou Y, Shi H. [abstract].

Am J Transplant. 2019; 19 (suppl 3).

28) Periphery Blood ddcfDNA Can Significantly Differentiate Acute Humoral Rejection from Banff’s Type I Acute Rejection in Kidney Transplantation

Wang R, Jiang T, Shen J, Ge J, Lei W, Yang X, Deng H, Kong W, Zhou J.[abstract].

Am J Transplant. 2019; 19 (suppl 3).

29) Research progress of donor-derived cell-free DNA in transplanted kidney injury

Jiang Tingya Zhou Yang Cheng Dongrui, "Chinese Journal of Organ Transplantation" September 2019, Volume 40, Issue 9

30) Dynamics of early post-operative plasma ddcfDNA levels in kidney transplantation: a single-center pilot study

Shen J, Zhou Y, Chen Y, Li X, Lei W, Ge J, Peng W, Wu J, Liu G, Yang G, Shi H, Chen J, Jiang T, Wang R.

Transpl Int. 2019 Feb;32(2):184-192.

31) A Noninvasive and Donor-independent Method Simultaneously Monitors Rejection and Infection in Patients With Organ Transplant

Zhou Y, Yang G, Liu H, Chen Y, Li X, Ge J, Wang X, Niu H, Dong W, Jiang T, Shi H, Peng L, Liu L.

Transplant Proc. 2019 Jul-Aug;51(6):1699-1705.

32) Research progress on detection of pathogenic infections after organ transplantation

Wang Xiaochen, Ge Jun, Chen Yawen, Jiang Tingya, Li Xiaofeng, Yang Gongda, Zhou Yang, Wang Rending. "Organ Transplantation" 2018, 9(06): 474-477.

33) Cell-free DNA in acute organ transplantationApplication in repulsion reaction detection

Chen Yawen, Jiang Tingya, Yang Gongda, Zhou Yang, Tang Xiaotian, Liu Lei, "Chinese Journal of Organ Transplantation" 2018,39(1):58-61.

Oral report at international conference on cooperation

(ATC/ESOT/TTS)

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1) Simultaneously detection of ddcfDNA in plasma and urine assist to determine the type of rejection in renal transplant patients

[abstract]. TTS 2020: Oral Presentation 310.2. (https://virtual.tts.org/virtual/lecture/285).

2) Urine Donor-derived Cell-free is Valuable for Predicting BK Polyomavirus-associated Nephropathy in Kidney Transplant Recipients

[abstract]. Am J Transplant. 2021; 21 (suppl 3). (https://atcmeetingabstracts.com/abstract/urine-donor-derived-cell-free-is-valuable-for-predicting-bk-polyomavirus-associated-nephropathy-in-kidney-transplant-recipients/).

3) Donor derived cell-free DNA in donor specific antibody positive kidney transplant recipient

[abstract]. ESOT 2019: Oral Presentation; （https://onlinelibrary.wiley.com/doi/epdf/10.1111/tri.13507 ）

4) Detecting donor derived cell free DNA levels to identify BKVAN and BKV infection combined TCMR

[abstract]. ESOT 2019: Oral Presentation; 4395346

5) Simultaneous quantification of ddcfDNA and noninvasive genotyping of donor’s HLA in renal transplant patients by next-generation sequencing

[abstract]. ESOT 2019: Oral Presentation; 4395393.

6) Detecting donor derived cell-free DNA in urine identify BKVN with graft injury in BK viruria kidney transplant recipients

ESOT 2019: Oral Presentation; 4396189