ALLODX / RESEARCH
Immune Repertoire Sequencing
Focus on TCR beta-chain repertoire analysis to examine receptor composition, clonal distributions, and changes across study time points.
Describe clonality through receptor sequences
Immune repertoire sequencing examines rearranged TCR or BCR sequences to characterize receptor diversity and clonal distributions. This service focuses on TCR beta-chain analysis; other chains and BCR projects require separate scoping.
Core analyses
V/J usage and rearrangements
Summarize V/J gene usage and combination frequencies to compare repertoire structure.
Explore service →Clonotypes and abundance
Report abundant clonotypes, top sequences, and relative frequencies; compare shared clones and longitudinal changes.
Explore service →Diversity and evenness
Describe repertoire structure using Shannon, Simpson, and related metrics, interpreted with sampling and sequencing depth.
Explore service →Design comparisons for transplantation and immune research
Comparisons may include donors and recipients, pre- and post-transplant samples, and longitudinal follow-up. Sample types, nucleic acid input, and library strategies should be harmonized, with controls and biological replicates defined.
Diversity alone does not determine immune competence, infection risk, or transplant outcomes. Clonal expansion does not by itself establish antigen specificity; interpretation requires the study context and complementary evidence.
Technical background and references
Services on this page are for research use. Project scope, sample requirements, and deliverables are defined in the agreed study plan.
Start with your research question
Tell us your research area, sample type, study groups, and intended outcomes. Together, we will define the technical plan and deliverables.
Discuss your research needs ↗